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Updated: May 6, 2026
Prediction of HIV-1 Coreceptor Usage Tropism by Sequence Analysis using a Genotypic Approach
Published on: December 1, 2011
Determination of HIV-1 co-receptor usage
Mariangela Cavarelli1, Gabriella Scarlatti
1Viral Evolution and Transmission Unit, Department of Immunology, Transplant, and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy.
Abstract:
Human immunodeficiency virus type I (HIV-1) infects target cells through interaction with the CD4 molecule and chemokine receptors, mainly the β-chemokine receptor 5 (CCR5) and the α-chemokine receptor 4 (CXCR4). Viral isolates can be phenotypically classified based on the co-receptor they utilize to infect target cells. In this chapter, methods to determine the co-receptor usage of HIV-1 variants are described.
