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Assessing the Development of Murine Plasmacytoid Dendritic Cells in Peyer's Patches Using Adoptive Transfer of Hematopoietic Progenitors
Published on: March 17, 2014
Myeloid and plasmacytoid dendritic cells: reference ranges in the peripheral blood of healthy children
O Ciocarlie1, A Heinze, M C Elze
1Hannover Medical School, IFB-Tx, Institute of Cellular Therapeutics, GMP-DU, Hannover, Germany.
Insights
This review summarizes research on dendritic cell counts in healthy children. It highlights the scarcity of data and the need for standardized methods for accurate quantification in pediatric peripheral blood.
Area of Science:
- Immunology
- Pediatric Hematology
Background:
- Dendritic cells (DCs) play crucial roles in immune regulation.
- Limited data exists on normal DC values in healthy pediatric populations.
- Existing studies often include children as controls in disease-focused research.
Purpose of the Study:
- To consolidate available data on absolute dendritic cell counts in healthy children.
- To address the gap in pediatric reference ranges for dendritic cells.
- To emphasize the importance of standardized sample processing for reliable results.
Main Methods:
- Systematic review of 8 publications.
- Focus on studies quantifying absolute dendritic cell counts.
- Inclusion of research using minimally manipulated peripheral blood samples processed within 24 hours.
Main Results:
- Identified 8 relevant publications on pediatric dendritic cell quantification.
- Highlighted the heterogeneity in reported DC values.
- Underscored the need for consistent methodologies.
Conclusions:
- There is a significant need for more research on dendritic cell levels in healthy children.
- Standardized protocols for sample handling and processing are essential for establishing reliable pediatric reference ranges.
- Accurate DC quantification is vital for future pediatric immunology studies and clinical applications.
Abstract:
To date, few publications report on dendritic cells values in healthy children and mostly are found as control groups in studies focused on either allergic and autoimmune diseases or malignancies. This report provides an overview of 8 publications regarding absolute dendritic cells quantification in the peripheral blood of healthy children by using minimum manipulated samples processed within 24 hours.
