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ERF115 controls root quiescent center cell division and stem cell replenishment
Jefri Heyman1, Toon Cools, Filip Vandenbussche
1Department of Plant Systems Biology, VIB, B-9052 Gent, Belgium.
Science (New York, N.Y.)
|October 26, 2013
Summary
The ERF115 transcription factor controls quiescent center (QC) cell division in plant roots. Antagonistic mechanisms regulate ERF115, ensuring stem cell niche longevity and root development.
Area of Science:
- Plant biology
- Developmental biology
- Cell cycle regulation
Background:
- The quiescent center (QC) is crucial for root development, maintaining surrounding stem cell fate.
- QC cells self-renew slowly despite being near highly proliferative cells.
Purpose of the Study:
- To identify factors regulating QC cell division rate.
- To understand the mechanism maintaining stem cell niche longevity.
Main Methods:
- Identified ERF115 transcription factor as a key regulator.
- Investigated ERF115's role in activating phytosulfokine PSK5.
- Analyzed regulation by APC/C(CCS52A2) ubiquitin ligase and brassinosteroid signaling.
Main Results:
- ERF115 acts as a rate-limiting factor for QC cell division.
- ERF115 activates the PSK5 peptide hormone.
- Proteolysis by APC/C(CCS52A2) restrains ERF115, while brassinosteroids promote its expression.
- ERF115 activity is triggered by damage to surrounding stem cells.
Conclusions:
- ERF115 and its regulators form an antagonistic system controlling QC cell division.
- This mechanism ensures stem cell niche longevity during root development.
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