Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Regulatory peptides and the lung.

S R Bloom, J M Polak

    Pediatric Pulmonology
    |May 1, 1985
    PubMed
    Summary

    Regulatory peptides like vasoactive intestinal peptide (VIP) and bombesin are abundant in mammalian respiratory tracts, influencing functions from mucus secretion to lung growth. Their distribution varies by species and developmental stage, with altered levels observed in neonatal lung disease.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Localization of the enzyme neutral endopeptidase to the human synovium.

    The Journal of rheumatology·1992
    Same author

    Redistribution of secretory granule components precedes that of synaptic vesicle proteins during differentiation of a neuronal cell line in serum-free medium.

    Neuroscience·1992
    Same author

    Immunological detection of nitric oxide synthase(s) in human tissues using heterologous antibodies suggesting different isoforms.

    Histochemistry·1992
    Same author

    Expression of the tissue specific splicing protein SmN in neuronal cell lines and in regions of the brain with different splicing capacities.

    Brain research. Molecular brain research·1992
    Same author

    Autoradiographic localization of endothelin-1 binding sites in human colonic cancer tissue.

    The Journal of pathology·1992
    Same author

    Effect of Helicobacter pylori on gastric somatostatin in duodenal ulcer disease.

    Lancet (London, England)·1992

    Area of Science:

    • Neuroendocrinology
    • Pulmonary Biology
    • Comparative Anatomy

    Background:

    • Regulatory peptides are crucial signaling molecules found in peripheral tissues and nerves.
    • The lung is a significant reservoir for various biologically active peptides.
    • Understanding peptide distribution in the respiratory system is key to pulmonary function and development.

    Purpose of the Study:

    • To investigate the presence and localization of key regulatory peptides in mammalian respiratory tracts.
    • To explore the potential roles of these peptides in respiratory physiology and development.
    • To examine peptide distribution in human fetal and neonatal lungs and in pulmonary disease.

    Main Methods:

    • Immunohistochemical examination of respiratory tracts from rat, guinea pig, and cat.
    • Analysis of peptide distribution in human fetal, neonatal, and diseased lungs.
    • Quantification of specific peptides such as vasoactive intestinal peptide (VIP) and bombesin.

    Main Results:

    • Significant quantities of VIP, bombesin, substance P, somatostatin, and cholecystokinin were detected in mammalian respiratory tracts.
    • VIP nerves were concentrated in the upper respiratory tract, associated with glands and smooth muscle, suggesting secretomotor and smooth muscle relaxation roles.
    • Bombesin localized to epithelial APUD cells, particularly in fetuses, indicating a role in pulmonary growth; substance P was found in sensory nerve fibers near the epithelium.
    • In humans, bombesin and VIP were abundant, with bombesin cells concentrated in fetal/neonatal bronchioles. Bombesin levels were reduced in neonatal acute hyaline membrane disease.

    Conclusions:

    • Regulatory peptides are widely distributed in the respiratory system, with distinct localizations and potential functions.
    • Bombesin and VIP play significant roles in human lung development and may be implicated in neonatal respiratory disorders.
    • Peptide distribution patterns offer insights into respiratory control, growth, and disease pathogenesis.

    Related Experiment Videos