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Marginal corneal vascular arcades.

Yalin Zheng1, Abigail E Kaye, Alexander Boker

  • 1Department of Eye and Vision Science, University of Liverpool, Liverpool, United Kingdom.

Investigative Ophthalmology & Visual Science
|October 26, 2013
PubMed
Summary

The marginal corneal arcades (MCA) form a network of elliptical vascular loops in the cornea, with blood flow primarily in the inferior quadrant. These vessels show tortuosity and fractal patterns, with no significant changes extending into the limbal region.

Keywords:
cornealimbusmarginal corneal arcadesvessels

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Area of Science:

  • Ophthalmology
  • Corneal Imaging
  • Vascular Biology

Background:

  • The marginal corneal arcades (MCA) are a network of vessels at the limbus.
  • Understanding their structure and flow is crucial for corneal health.

Purpose of the Study:

  • To determine the geometrical metrics and filling patterns of the marginal corneal arcades (MCA).

Main Methods:

  • Indocyanine green dye angiography (ICGA) was used to image the MCA in fellow eyes of patients with unilateral keratitis.
  • Images were analyzed using custom software to quantify vascular loop area, circumference, axes, branching, tortuosity, and fractal dimension.

Main Results:

  • The MCA consist of branched, interlinked elliptical loops with a mean area of 11.87 × 10⁻³ mm² and circumference of 422.5 μm.
  • Vessel filling occurred first in the inferior quadrant, followed by superior, nasal, and temporal quadrants.
  • Significant inter-subject variability was observed in vessel loop area and branch number; vessels were tortuous with a fractal dimension of 1.51.

Conclusions:

  • The MCA form a branched, interconnected network of elliptical loops supporting circumferential blood flow in the corneal periphery.
  • No significant changes in the vascular pattern were observed extending into the limbal region.