Related Experiment Video

Updated: May 6, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
28:13

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

34.6K

[Immune status of patients with persistent atrial fibrillation and coronary heart disease]

L M Vasilets, N E Grigoriadi, N S Karpunina

    Klinicheskaia Meditsina
    |October 29, 2013
    PubMed

    Insights

    Chlamydial infections trigger a strong immune response in coronary heart disease (CHD) patients, particularly those with atrial fibrillation (AF). Inflammation markers predict AF development and myocardial remodeling in CHD patients.

    Area of Science:

    • Immunology
    • Cardiology
    • Infectious Diseases

    Context:

    • Coronary heart disease (CHD) is a significant global health concern.
    • Atrial fibrillation (AF) is a common complication in CHD patients.
    • The role of infectious agents in cardiovascular disease pathogenesis is increasingly recognized.

    Purpose:

    • To investigate the immune response to chlamydial infection in patients with CHD.
    • To determine the relationship between chlamydial infection, inflammation, and AF in CHD.
    • To assess the prognostic value of inflammatory markers for AF development and myocardial remodeling in CHD with AF.

    Summary:

    • Immune response to chlamydial infection was evaluated in CHD patients.
    • The immune response was most pronounced in CHD patients with atrial fibrillation (AF).
    • A strong correlation was observed between past chlamydial infection and inflammatory markers like C-reactive protein (CRP) and tumor necrosis factor-alpha (TNF-alpha).
    • These markers demonstrated high prognostic value for AF development and were linked to myocardial remodeling in CHD with AF.

    Impact:

    • The study confirms the significant role of inflammation in the pathogenesis of AF within the context of CHD.
    • Findings highlight potential diagnostic and therapeutic targets related to chlamydial infection and inflammation in managing CHD patients with AF.

    More Related Videos

    Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation08:10

    Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

    Published on: July 20, 2022

    2.9K
    The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation23:33

    The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

    Published on: February 28, 2012

    84.2K

    Related Concept Videos

    Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

    Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

    The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
    1.3K
    Acute Coronary Syndrome III: Diagnostic Studies01:30

    Acute Coronary Syndrome III: Diagnostic Studies

    Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
    502
    Rheumatic Heart Disease III: Medical Management01:21

    Rheumatic Heart Disease III: Medical Management

    Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
    548
    Coronary Artery Disease III: Clinical Manifestations01:30

    Coronary Artery Disease III: Clinical Manifestations

    Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
    632
    Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

    Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

    The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
    961
    Coronary Artery Disease IV: Preventive Measures01:26

    Coronary Artery Disease IV: Preventive Measures

    Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
    893