Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

2.7K
In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
2.7K
Motor Unit Stimulation01:20

Motor Unit Stimulation

4.7K
When the neuron of a motor unit fires an action potential, it triggers a series of events, leading to a twitch contraction in the muscle fibers. The process of excitation-contraction coupling is crucial in relaying the action potential to the muscle fibers.
The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...
4.7K
Generation of Action Potential in Skeletal Muscles01:24

Generation of Action Potential in Skeletal Muscles

9.3K
Every cell in the body maintains a membrane potential due to an uneven distribution of positive and negative charges across its plasma membrane. The membrane potential is measured in millivolts and quantifies the difference in charge across the membrane.
Like neurons, muscle cells are also regarded as excitable due to their capacity to change in response to stimuli, primarily due to voltage-gated ion channels embedded in their plasma membranes, which get activated by alterations in the...
9.3K
Excitation-Contraction Coupling in Skeletal Muscles01:20

Excitation-Contraction Coupling in Skeletal Muscles

18.0K
Excitation-contraction coupling is a series of events that occur between generating an action potential and initiating a muscle contraction. It occurs at the triad, a structure found in skeletal muscle fibers that comprise a T-tubule and terminal cisternae of the sarcoplasmic reticulum on each side. These triads are visible in longitudinally sectioned muscle fibers. They are typically located at the A-I junction — the junction between the A and I bands of the sarcomere.
When an action...
18.0K
Muscle Contraction01:15

Muscle Contraction

76.6K
 
76.6K
Smooth Muscle Contraction01:25

Smooth Muscle Contraction

8.7K
Smooth muscle contraction is a complex process vital for various bodily functions, from maintaining blood vessel tension to facilitating the movement of food through the digestive tract. Unlike striated muscles, smooth muscle contraction begins more slowly and lasts longer.
The onset of contraction is triggered by an increase in calcium ions within the sarcoplasm, similar to the process in striated muscle. However, smooth muscles have a relatively smaller reservoir of the sarcoplasmic...
8.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CONTENT OF CYTOSKELETON PROTEINS IN OOCYTES OF THIRD GENERATION DROSOPHILA MELANOGASTER FRUIT FLIES OBTAINED AFTER A 44.5-DAY SPACE FLIGHT.

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine·2018
Same author

[Biophysical Model of Contractile Activity of Muscle Cells].

Biofizika·2016
Same author

[Early Development under Microgravity Conditions].

Biofizika·2015
Same author

[Cytochrome C content and mitochondrial activity in rat's cardiac and skeletal muscle cells in the course of 3-day gravitational unloading].

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine·2015
Same author

[Desmin content and transversal stiffness of the left ventricle mouse cardiomyocytes and skeletal muscle fibers after a 30-day space flight on board "BION-M1" biosatellite].

Biofizika·2015
Same author

[Structure of the cortical cytoskeleton of the left cardiac ventricle hystiocytes and of soleus muscle fibers in rats following short-time suspension].

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine·2014

Related Experiment Video

Updated: May 6, 2026

Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles
14:02

Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles

Published on: November 1, 2012

24.1K

[Interaction between muscle cell and external mechanical field: a model study].

N S Biriukova, I V Ogneva

    Biofizika
    |October 29, 2013
    PubMed
    Summary
    This summary is machine-generated.

    A new mathematical model explains muscle cell membrane mechanics under external forces. Hindlimb suspension causes significant deformation in rodent soleus muscles, linked to cortical cytoskeleton stiffness.

    More Related Videos

    Myo-mechanical Analysis of Isolated Skeletal Muscle
    08:42

    Myo-mechanical Analysis of Isolated Skeletal Muscle

    Published on: February 22, 2011

    29.1K
    A Murine Model of Muscle Training by Neuromuscular Electrical Stimulation
    08:24

    A Murine Model of Muscle Training by Neuromuscular Electrical Stimulation

    Published on: May 9, 2012

    22.1K

    Related Experiment Videos

    Last Updated: May 6, 2026

    Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles
    14:02

    Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles

    Published on: November 1, 2012

    24.1K
    Myo-mechanical Analysis of Isolated Skeletal Muscle
    08:42

    Myo-mechanical Analysis of Isolated Skeletal Muscle

    Published on: February 22, 2011

    29.1K
    A Murine Model of Muscle Training by Neuromuscular Electrical Stimulation
    08:24

    A Murine Model of Muscle Training by Neuromuscular Electrical Stimulation

    Published on: May 9, 2012

    22.1K

    Area of Science:

    • Biophysics
    • Cellular Mechanics
    • Skeletal Muscle Physiology

    Context:

    • Muscle cell membranes are crucial for cellular function and mechanical response.
    • Understanding muscle deformation is vital for studying conditions like muscle atrophy.
    • External mechanical forces significantly influence cellular structures.

    Purpose:

    • To develop a mathematical model of the muscle cell membrane incorporating external mechanical effects.
    • To quantitatively analyze muscle deformation in response to hindlimb suspension.
    • To investigate the relationship between muscle fiber deformation and cortical cytoskeleton properties.

    Summary:

    • A novel mathematical model based on the thin elastic rods theory was proposed for the muscle cell membrane.
    • The model accounts for external mechanical influences on muscle cells.
    • Quantitative analysis revealed maximal deformation in soleus muscle fibers of rodents subjected to hindlimb suspension.

    Impact:

    • This research provides insights into the mechanical behavior of muscle cells.
    • Findings connect muscle deformation magnitude to the stiffness of the cortical cytoskeleton.
    • The study contributes to a better understanding of muscle adaptation to mechanical unloading.