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Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

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Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
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Bioavailability Enhancement: Drug Permeability Enhancement01:27

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After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
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Bioavailability Enhancement: Drug Solubility Enhancement01:16

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Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
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Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

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Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
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Bioequivalence of Drugs: Drugs with Multiple Indications01:09

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The concept of therapeutic equivalence (TE) in drugs with multiple indications is complex. A generic drug may be therapeutically equivalent to a brand-name product for one specific indication, but this doesn't necessarily mean it's equivalent for all other indications. Evidence of TE in one patient group and bioequivalence shown in healthy volunteers can support—but not confirm—TE for other indications. However, definitive proof requires individual clinical studies for each...
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Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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In vitro Digestion of Emulsions in a Single Droplet via Multi Subphase Exchange of Simulated Gastrointestinal Fluids
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[Multiple emulsions; bioactive compounds and functional foods].

Francisco Jiménez-Colmenero1

  • 1Instituto de Ciencia y Tecnología de Alimentos y Nutrición (ICTAN-CSIC) (anteriormente Instituto del Frío). Dpto. Productos, Laboratorio de Carne y Productos Cárnicos. Ciudad Universitaria. Madrid. España.

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Summary

Functional foods, driven by diet and wellness research, are enhanced by multiple emulsions. This technology optimizes bioactive compound delivery, improving food’s nutritional and sensory qualities.

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Area of Science:

  • Food Science and Technology
  • Nutritional Science
  • Material Science

Context:

  • Growing scientific evidence links diet to health and wellness, driving the demand for functional foods.
  • Functional foods are key drivers in new product development within the food industry.
  • Multiple emulsions offer novel avenues for functional food design and product innovation.

Purpose:

  • To summarize the types, characteristics, and formation of multiple emulsions.
  • To explore the potential location of bioactive compounds within multiple emulsions.
  • To outline the applications of multiple emulsions in creating healthy and functional foods.

Summary:

  • Multiple emulsions serve as intermediate products or food ingredients in technological strategies.
  • They optimize the presence of bioactive compounds, particularly hydrophilic ones, in food products.
  • Applications include modifying lipid content (reduced fat/calories, improved fatty acid profile), reducing sodium, and masking flavors.

Impact:

  • Enhances the development of innovative healthy and functional food products.
  • Improves the nutritional profile of foods through optimized bioactive compound delivery.
  • Offers significant potential for improving sensory attributes and consumer acceptance of food products.