Nivetetracyclates A and B: novel compounds isolated from Streptomyces niveus
Caixia Chen1, Xueting Liu, Wael M Abdel-Mageed
1CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences , Beijing, 100101, P.R. China, Pharmacognosy Department, Faculty of Pharmacy, Assiut University , Assiut, Egypt, Laboratory of Molecular Vector Biology, Haidian Center for Disease Prevention and Control , Haidian District, Beijing, 100094, P.R. China, Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen , Old Aberdeen, AB24 3UE, Scotland, U.K., and Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing, 100050, P.R. China.
Abstract:
A high-throughput screening of a microbial natural product library led to the discovery of two novel compounds named nivetetracyclates A and B (1 and 2), which were produced by Streptomyces niveus designated as LS2151. The backbone of the compounds contains a hydrotetracyclate not previously reported from a natural source. The structures of the compounds were elucidated by spectroscopic methods. The nivetetracyclates exhibited activity against human HeLa cells.
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