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Inflammatory Bowel Disease IV: Pharmacological Management01:29

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Treatment approaches for psychological disorders fall into three main categories: psychological, biological, and sociocultural. Each approach targets different aspects of mental health, requiring varying levels of education and training.
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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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Biological therapies for psoriasis.

Bobbak Mansouri1, Mahir Patel, Alan Menter

  • 1Dermatology Research FellowBaylor University Medical Center, Division of Dermatology , 3900 Junius Street, Suite 125, Dallas, TX 75204 , USA.

Expert Opinion on Biological Therapy
|October 29, 2013
PubMed
Summary

Biological therapies have advanced psoriasis treatment by targeting key pathways like IL-23/Th17. Future advancements include biosimil agents and pharmacogenomics for personalized psoriasis care.

Area of Science:

  • Immunodermatology
  • Inflammatory Diseases
  • Psoriasis Pathogenesis

Background:

  • Biological therapies have transformed moderate-to-severe psoriasis management.
  • Understanding of disease pathogenesis has identified targets in the IL-23/Th17 pathway.
  • Ongoing monitoring of current therapies for long-term efficacy and safety is crucial.

Purpose of the Study:

  • To review current understanding of psoriasis immunopathogenesis and therapeutic targets.
  • To cover approved and emerging biological therapies targeting key inflammatory mediators.
  • To discuss special circumstances for biological agent use, biosimil debates, and future roles.

Main Methods:

  • Comprehensive review of current scientific literature on psoriasis immunopathogenesis.

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  • Analysis of biological therapies targeting TNF-α, IL-12/23p40, IL-17, and IL-23p19.
  • Examination of evidence regarding biosimilar therapies and their implications.

    • Main Results:

    • Significant progress in psoriasis treatment efficacy due to improved understanding of pathogenesis.
    • Identification of specific biological targets like IL-23/Th17 pathway mediators.
    • Review of various biological agents and their application in diverse patient populations.

    Conclusions:

    • Psoriasis treatment is more effective but requires improvement for non-responders, safety concerns, and variants like pustular psoriasis.
    • Pharmacogenomics is essential for future individualized psoriasis care.
    • Biosimilar agents offer potential for improved global access to psoriasis treatments.