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Published on: October 31, 2013
Slowing DNA translocation through a nanopore using a functionalized electrode
Padmini Krishnakumar1, Brett Gyarfas, Weisi Song
1Department of Physics, ‡Biodesign Institute, and §Department of Chemistry and Biochemistry, Arizona State University , Tempe, Arizona 85287, United States.
Abstract:
Nanopores were fabricated with an integrated microscale Pd electrode coated with either a hydrogen-bonding or hydrophobic monolayer. Bare pores, or those coated with octanethiol, translocated single-stranded DNA with times of a few microseconds per base. Pores functionalized with 4(5)-(2-mercaptoethyl)-1H-imidazole-2-carboxamide slowed average translocation times, calculated as the duration of the event divided by the number of bases translocated, to about 100 μs per base at biases in the range of 50 to 80 mV.
