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CLOVES syndrome.

Jacob Bloom1, Joseph Upton

  • 1Division of Plastic Surgery, Boston Children's Hospital; and the Division of Plastic Surgery, Beth Israel Deaconess Medical Center, Boston, MA.

The Journal of Hand Surgery
|October 29, 2013
PubMed
Summary
This summary is machine-generated.

CLOVES syndrome, characterized by congenital lipomatous overgrowth and vascular malformations, is a distinct overgrowth disorder. Diagnosis relies on specific anomalies, distinguishing it from other overgrowth conditions.

Keywords:
CLOVESovergrowth syndromesvascular anomalies

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Area of Science:

  • Genetics and Developmental Biology
  • Pediatric Endocrinology
  • Clinical Genetics

Background:

  • Overgrowth syndromes represent a complex group of genetic disorders.
  • A specific cohort presented with congenital lipomatous overgrowth, dysregulated fat deposits, and mixed vascular malformations.
  • The CLOVES acronym was derived from key features: Congenital Lipomatous Overgrowth, Vascular malformations, Epidermal nevi, and Scoliosis/Spinal deformities.

Purpose of the Study:

  • To define and characterize CLOVES syndrome as a distinct clinical entity.
  • To identify diagnostic criteria for CLOVES syndrome.
  • To differentiate CLOVES syndrome from other known overgrowth disorders.

Main Methods:

  • Clinical examination of patients with overgrowth syndromes.
  • Radiographic assessment to identify skeletal and spinal anomalies.
  • Phenotypic analysis focusing on limb, truncal, cutaneous, and spinal manifestations.

Main Results:

  • Patients exhibited congenital lipomatous overgrowth, dysregulated fat deposits, and mixed vascular malformations.
  • Upper limb anomalies were present but variable.
  • Foot, truncal, cutaneous, and spinal anomalies were identified as particularly diagnostic for CLOVES syndrome.

Conclusions:

  • CLOVES syndrome is a distinct clinical entity.
  • Diagnosis is established through clinical and radiographic examinations.
  • The unique overgrowth pattern allows for clear distinction from other overgrowth syndromes.