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ACE levels may affect cystatin C measurements.

Guido Filler1, Roberta A Berard2, Shih-Han Susan Huang2

  • 1Department of Pediatrics, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON, N6A 5W9, Canada; Department of Medicine, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON, N6A 5W9, Canada; Department of Pathology and Laboratory Medicine, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON, N5A 5A5, Canada.

Clinical Biochemistry
|October 29, 2013
PubMed
Summary

Elevated angiotensin-converting enzyme (ACE) levels may non-specifically increase cystatin C in pediatric sarcoidosis patients. This occurs even without kidney damage or impaired kidney function, suggesting ACE as a potential factor.

Keywords:
Angiotensin converting enzymeCystatin CGlomerular filtration rateSarcoidosis

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Area of Science:

  • Nephrology
  • Endocrinology
  • Immunology

Background:

  • Sarcoidosis is an inflammatory disease that can affect multiple organs.
  • Angiotensin-converting enzyme (ACE) levels are often elevated in sarcoidosis.
  • Cystatin C is a marker of kidney function, but can be influenced by other factors.

Observation:

  • A case report examined a 12-year-old patient with presumed sarcoidosis.
  • The study analyzed the correlation between ACE levels and cystatin C concentrations.
  • Glomerular filtration rate (GFR) was assessed using nuclear medicine methods.

Findings:

  • A strong correlation was observed between ACE levels and cystatin C concentration.
  • This correlation persisted in the absence of renal pathology and abnormal renal function.
  • The findings suggest ACE may influence cystatin C independently of GFR.

Implications:

  • Elevated ACE levels might lead to non-specific elevations in cystatin C.
  • This association could impact the interpretation of cystatin C as a sole marker for renal function in certain conditions.
  • Further research is warranted to elucidate the mechanisms behind this relationship.