Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nociception01:44

Nociception

28.4K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
28.4K
Pain01:20

Pain

2.1K
Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
2.1K
Analgesia and Pain Management01:25

Analgesia and Pain Management

3.4K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
3.4K
Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

1.8K
Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
1.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reply to "Defining the boundary between pain and suffering" by Cohen, Quintner and Weisman.

Pain·2026
Same author

Reply to Noe-Steinmuller and Tesarz.

Pain·2026
Same author

Chinese people's experience of cancer in the UK: a reflexive thematic analysis.

Frontiers in psychology·2026
Same author

Experience of opioid cessation after surgery in opioid-naïve patients in the United Kingdom: A qualitative study.

British journal of pain·2026
Same author

Reply to Duffee and Tate.

Pain·2026
Same author

Qualitative investigation of the experiences of older people living with persistent pain and frailty and their decision to seek support: findings from the POPPY-Q study.

BMJ open·2025

Related Experiment Video

Updated: May 6, 2026

Dynamic Quantitative Sensory Testing to Characterize Central Pain Processing
09:16

Dynamic Quantitative Sensory Testing to Characterize Central Pain Processing

Published on: February 16, 2017

18.2K

How do people understand their neuropathic pain? A Q-study.

Sally Martin1, Clare Daniel, Amanda C de C Williams

  • 1Previously, Research Department of Clinical, Educational and Health Psychology, University College London, London, UK Pain Management Centre and Facial Pain Service, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK Research Department of Clinical, Educational and Health Psychology, University College London, London, UK.

Pain
|October 29, 2013
PubMed
Summary
This summary is machine-generated.

Understanding neuropathic pain (NP) is challenging for patients. This study reveals diverse patient views on NP causes and treatments, highlighting a need for clearer medical explanations to improve pain management.

Keywords:
Lay understandingNerve damagePsychological treatment

More Related Videos

A Protocol of Manual Tests to Measure Sensation and Pain in Humans
07:28

A Protocol of Manual Tests to Measure Sensation and Pain in Humans

Published on: December 19, 2016

20.9K
A Quantitative Sensory Testing Paradigm to Obtain Measures of Pain Processing in Patients Undergoing Breast Cancer Surgery
07:14

A Quantitative Sensory Testing Paradigm to Obtain Measures of Pain Processing in Patients Undergoing Breast Cancer Surgery

Published on: January 18, 2018

9.1K

Related Experiment Videos

Last Updated: May 6, 2026

Dynamic Quantitative Sensory Testing to Characterize Central Pain Processing
09:16

Dynamic Quantitative Sensory Testing to Characterize Central Pain Processing

Published on: February 16, 2017

18.2K
A Protocol of Manual Tests to Measure Sensation and Pain in Humans
07:28

A Protocol of Manual Tests to Measure Sensation and Pain in Humans

Published on: December 19, 2016

20.9K
A Quantitative Sensory Testing Paradigm to Obtain Measures of Pain Processing in Patients Undergoing Breast Cancer Surgery
07:14

A Quantitative Sensory Testing Paradigm to Obtain Measures of Pain Processing in Patients Undergoing Breast Cancer Surgery

Published on: January 18, 2018

9.1K

Area of Science:

  • Neurology
  • Psychology
  • Pain Management

Background:

  • Neuropathic pain (NP) is often poorly understood by patients, even within specialist settings.
  • Explanations of NP may not align with patients' existing health beliefs.
  • Limited understanding can hinder effective pain self-management.

Purpose of the Study:

  • To explore how individuals with neuropathic pain conceptualize their condition.
  • To identify shared patient perspectives on the causes, influences, and treatments of NP.
  • To assess the integration of biopsychosocial models in patient understanding of NP.

Main Methods:

  • Q-methodology was used to recruit 79 participants with NP.
  • Participants sorted statements about NP based on agreement/disagreement.
  • Factor analysis identified shared constructions of NP.

Main Results:

  • Four distinct factors emerged, reflecting differing views on nerve damage, necessity of identifying cause, symptomatic treatment acceptability, psychological influences, and psychological treatment utility.
  • Patient viewpoints were linked to medical history, treatment experiences, and daily life impact.
  • A comprehensive biopsychosocial model of pain was weakly represented, with no single integrated model across participants.

Conclusions:

  • Patient conceptualizations of NP are diverse and not fully aligned with integrated pain models.
  • There is a significant need for improved, accessible explanations of NP within and beyond medical services.
  • Enhanced understanding is crucial for empowering patients to manage their pain and reduce its life impact.