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Rapid One-step Enzymatic Synthesis and All-aqueous Purification of Trehalose Analogues
Published on: February 17, 2017
Tandem Staudinger/aza-Wittig reaction of 6-azido-6-deoxycellulose derivative
Masaya Shibano1, Hiroshi Kamitakahara, Toshiyuki Takano
1Division of Forest and Biomaterials Science, Graduate School of Agriculture, Kyoto University, Kyoto, Japan.
Abstract:
The tandem Staudinger/aza-Wittig reaction of the 6-azido-6-deoxycellulose derivative (2) with triphenylphosphine and carbon disulfide afforded the corresponding 6-isothiocyanato-6-deoxycellulose derivative (3) in 47.3% yield. Compound 3 was further reacted with 4'-aminobenzo-15-crown ether to afford the crown ether-containing 6-N-thioureido-6-deoxycellulose derivative (4) in 70.0% yield. Compound 4 was also obtained in 28.7% yield from the one-pot reaction (tandem Staudinger/aza-Wittig reaction/thiocarbamoylation) of compound 2. The tandem Staudinger/aza-Wittig reaction is a useful alternative to the Huisgen reaction for the synthesis of functional cellulose derivatives from 6-azido-6-deoxycellulose derivatives.
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