Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Exercise and Cardiovascular Response01:20

Exercise and Cardiovascular Response

6.9K
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
6.9K
Exercise and Cardiac Output01:17

Exercise and Cardiac Output

4.0K
Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
Sustained exercise increases the muscles' oxygen demand, which can be...
4.0K
Factors Influencing Heart Rate01:30

Factors Influencing Heart Rate

5.6K
The heart rate, or pulse rate, is a vital indicator of cardiovascular health. It reflects the number of times the heart beats per minute. Various physiological and environmental factors influence heart rate, increasing or decreasing cardiac output. Understanding these factors is crucial for assessing heart function and identifying potential health issues.
Let us explore the significant factors affecting heart rate, including age, body temperature, posture, acute pain, chemical influences,...
5.6K
Exercise Stress Test01:26

Exercise Stress Test

2.3K
Introduction
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes
2.3K
Regulation of Heart Rates01:31

Regulation of Heart Rates

6.2K
The regulation of heart rate is a complex process controlled by the autonomic nervous system (ANS), hormonal influences, and intrinsic cardiac mechanisms. The ANS has two main components: the sympathetic nervous system (SNS) and the parasympathetic nervous system (PNS).
The SNS increases heart rate through the release of norepinephrine and epinephrine, which act on beta-1 adrenergic receptors in the heart. This action increases the rate of depolarization in the sinoatrial (SA) node, the heart's...
6.2K
Cardiac Output I:Effect of Heart Rate on Cardiac Output01:19

Cardiac Output I:Effect of Heart Rate on Cardiac Output

3.4K
Cardiac Output
Cardiac output (CO) refers to the total amount of blood ejected by one of the ventricles in liters per minute (L/min). In a resting adult, CO ranges from 5 to 6 L/min, adjusting according to the body's metabolic requirements.
Effect of Heart Rate on Cardiac Output
Cardiac output adapts to metabolic demands during stress, physical activity, or illness. The autonomic nervous system regulates heart rate via the sinoatrial node. The parasympathetic nervous system decreases heart...
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correspondence: A two-step algorithm for pharmacologic management of COPD: Bridging foundational and personalized medicine.

Respiratory medicine·2026
Same author

Association Between Chronic PM2.5 Exposure and CT-Detected Lung Abnormalities in the SPIROMICS Cohort.

Annals of the American Thoracic Society·2026
Same author

Measuring nephron number in the healthy and diabetic rat kidney in vivo using MRI without contrast agents.

American journal of physiology. Renal physiology·2026
Same author

The evolving science of ventilation heterogeneity: From pathophysiology to personalized therapeutic approaches.

Respiratory medicine·2026
Same author

Ephaptic coupling and the source-sink effect of cardiac conduction.

The Journal of physiology·2026
Same author

Similarity of sputum mediator signatures between e-cigarette users and COPD depends on GOLD stage and type of e-cigarette: a pilot study.

PloS one·2026
Same journal

Cardiorespiratory Fitness and Age-Related Decline in Kidney Function among Individuals with Preserved Kidney Health: The Aging Kidney Study.

Medicine and science in sports and exercise·2026
Same journal

Objectively Measured Cardiorespiratory Fitness as a Potential Biomarker for Alzheimer's Disease Risk in Older Adults: Evidence from the Generation 100 Study.

Medicine and science in sports and exercise·2026
Same journal

The Effects of Eight-Week Traditional Aerobic Exercise and Exergaming on Dual-Task Performance and Prefrontal Cortex Activation in Older Adults.

Medicine and science in sports and exercise·2026
Same journal

The Impact of Cardiorespiratory Fitness on Cytotoxic T Cell Metabolism and Function.

Medicine and science in sports and exercise·2026
Same journal

Female Athletes Through the Lifespan: Clinical Considerations and a Call for Comprehensive Sports Medicine Healthcare.

Medicine and science in sports and exercise·2026
Same journal

Artificial Intelligence in Exercise Science and Sports Medicine.

Medicine and science in sports and exercise·2026
See all related articles

Related Experiment Video

Updated: May 6, 2026

Real-Time Electrocardiogram Monitoring During Treadmill Training in Mice
04:45

Real-Time Electrocardiogram Monitoring During Treadmill Training in Mice

Published on: May 5, 2022

2.5K

Exercise training improves heart rate variability after methamphetamine dependency.

Brett Andrew Dolezal1, Joy Chudzynski, Daniel Dickerson

  • 11Exercise Physiology Research Laboratory, Departments of Medicine and Physiology, David Geffen School of Medicine, UCLA, Los Angeles, CA; 2Integrated Substance Abuse Programs, Semel Institute, David Geffen School of Medicine, UCLA, Los Angeles, CA; and 3Department of Integrative Biology and Physiology, UCLA, Los Angeles, CA.

Medicine and Science in Sports and Exercise
|October 29, 2013
PubMed
Summary
This summary is machine-generated.

Methamphetamine dependence (MD) significantly reduces heart rate variability (HRV), indicating autonomic dysfunction. Exercise training effectively improved HRV in abstinent individuals, suggesting enhanced autonomic balance.

More Related Videos

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
09:16

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

Published on: January 22, 2016

17.6K
A Real-World High-Intensity Interval Training Protocol for Cardiorespiratory Fitness Improvement
08:27

A Real-World High-Intensity Interval Training Protocol for Cardiorespiratory Fitness Improvement

Published on: February 22, 2022

3.0K

Related Experiment Videos

Last Updated: May 6, 2026

Real-Time Electrocardiogram Monitoring During Treadmill Training in Mice
04:45

Real-Time Electrocardiogram Monitoring During Treadmill Training in Mice

Published on: May 5, 2022

2.5K
A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
09:16

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

Published on: January 22, 2016

17.6K
A Real-World High-Intensity Interval Training Protocol for Cardiorespiratory Fitness Improvement
08:27

A Real-World High-Intensity Interval Training Protocol for Cardiorespiratory Fitness Improvement

Published on: February 22, 2022

3.0K

Area of Science:

  • Cardiology
  • Neuroscience
  • Exercise Physiology

Background:

  • Heart rate variability (HRV) is a key indicator of autonomic nervous system (ANS) health.
  • Methamphetamine dependence (MD) is associated with autonomic dysfunction and reduced HRV.
  • Physical training is known to improve HRV in healthy individuals.

Purpose of the Study:

  • To compare HRV between recently abstinent methamphetamine-dependent (MD) individuals and drug-free (DF) controls.
  • To investigate the effects of an 8-week exercise training program on HRV in MD individuals.

Main Methods:

  • 50 participants (28 MD, 22 DF) underwent 5-minute resting heart rate (HR) recordings.
  • Time-domain (SDNN, RMSSD, pNN50) and frequency-domain (LFnu, HFnu, LF/HF) HRV parameters were calculated.
  • MD participants were randomized to an 8-week exercise intervention (ME) or a control group (MC).

Main Results:

  • The MD group exhibited significantly higher resting HR, LFnu, and LF/HF, and lower SDNN, RMSSD, pNN50, and HFnu compared to DF controls.
  • The ME group showed significant improvements in HRV indices (increased SDNN, RMSSD, pNN50, HFnu) and reduced HR, LFnu, and LF/HF after training.
  • No significant HRV changes were observed in the MC group.

Conclusions:

  • Recently abstinent individuals with methamphetamine dependence display diminished HRV.
  • Physical training can significantly enhance HRV in this population, suggesting improved autonomic balance and vagal modulation.