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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

360
Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
360
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

1.5K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.5K
Asthma-I: Introduction01:29

Asthma-I: Introduction

3.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.6K
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

4.7K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.7K
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

3.4K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.4K
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

73
Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
73

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Related Experiment Video

Updated: May 6, 2026

Murine Model of Allergen Induced Asthma
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Introduction to asthma and phenotyping.

Regina A Pillai1, William J Calhoun

  • 1Department of Internal Medicine, University of Texas Medical Branch, 4.118 John Sealy Annex, 301 University Blvd, Galveston, TX, 77555-0568, USA.

Advances in Experimental Medicine and Biology
|October 29, 2013
PubMed
Summary

Asthma

Area of Science:

  • Respiratory Medicine
  • Immunology

Background:

  • Asthma is a complex inflammatory airway disease with significant patient variability.
  • Current clinical asthma phenotypes overlap and do not precisely correlate with disease mechanisms or treatment responses.

Purpose of the Study:

  • To explore the potential of molecular phenotyping to address variability in asthma.
  • To advance asthma science and patient care through mechanistic understanding.

Main Methods:

  • The study discusses the concept and potential of molecular phenotyping in asthma research.
  • It contrasts molecular phenotyping with traditional clinical phenotyping approaches.

Main Results:

  • Clinical phenotypes are limited by overlap and poor mapping to pathophysiology and treatment.

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  • Molecular phenotyping offers a promising approach to dissect asthma's underlying mechanisms.

    • Conclusions:

    • Molecular phenotyping holds promise for understanding asthma's variability.
    • This approach may lead to more predictive and personalized therapeutics for asthma patients.