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Related Concept Videos

Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
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Asthma-I: Introduction01:29

Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
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Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

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Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
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Related Experiment Video

Updated: Jan 10, 2026

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
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Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

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Metabolomics in asthma.

Bruce A Luxon1

  • 1University of Texas Medical Branch, 301 University Blvd, Galveston, TX, 77555-1157, USA, baluxon@utmb.edu.

Advances in Experimental Medicine and Biology
|October 29, 2013
PubMed
Summary

Metabolomics analyzes small molecules to understand asthma and airway inflammation. This review explores current methods for discovering asthma biomarkers and their clinical application for personalized therapies.

Area of Science:

  • Biochemistry
  • Immunology
  • Clinical Medicine

Background:

  • Asthma and airway inflammation involve complex immune responses and diverse metabolic products.
  • Identifying characteristic metabolic signatures is crucial for understanding disease state and triggers.
  • Metabolomics, the analysis of small molecules (<1 kDa), faces challenges in sensitivity, specificity, and cost-effectiveness for clinical use.

Purpose of the Study:

  • To review the current state of metabolomics in asthma and airway inflammation research.
  • To focus on methods and instrumentation for biomarker discovery.
  • To discuss the future translation of metabolomic biomarkers into clinical practice for personalized asthma therapies.

Main Methods:

  • Quantitative analysis of small compounds (<1 kDa) in biological samples.

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  • Utilizing sophisticated instrumentation for metabolite identification and quantification.
  • Reviewing various analytical techniques and platforms for metabolomic profiling.

    • Main Results:

    • Metabolomic signatures can potentially indicate the state and causes of asthma.
    • Challenges remain in achieving the sensitivity, specificity, and cost-effectiveness required for clinical application.
    • Ongoing research focuses on identifying reliable metabolite biomarkers.

    Conclusions:

    • Metabolomics holds promise for diagnosing asthma and guiding patient-specific treatments.
    • Further development in analytical methods and clinical validation is necessary for successful translation.
    • Biomarker discovery through metabolomics can significantly advance personalized medicine in respiratory diseases.