RADAR: a rigorously annotated database of A-to-I RNA editing

Area of Science:

• Molecular Biology
• Genomics
• Bioinformatics

Background:

• High-throughput RNA sequencing has accelerated the discovery of RNA editing sites.
• Adenosine to inosine (A-to-I) RNA editing is a crucial post-transcriptional modification.
• Understanding RNA editing requires comprehensive and well-annotated datasets.

Purpose of the Study:

• To present RADAR, a rigorously annotated database for A-to-I RNA editing.
• To compile A-to-I RNA editing sites across multiple species (human, mouse, fly).
• To provide manually curated annotations and tissue-specific editing levels.

Main Methods:

• Data compilation from high-throughput RNA sequencing studies.
• Manual curation of identified A-to-I RNA editing sites.
• Development of an expandable database with tissue-specific editing information.

Main Results:

• RADAR includes a comprehensive collection of A-to-I RNA editing sites.
• Extensive manual annotations are provided for each editing site.
• Tissue-specific editing levels are included for functional assignment.

Conclusions:

• RADAR serves as a valuable resource for studying A-to-I RNA editing.
• The database facilitates the assignment of biological functions to RNA editing sites.
• RADAR supports research in molecular biology, genomics, and bioinformatics.