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Related Experiment Video

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The mouse Gene Expression Database (GXD): 2014 update.

Constance M Smith1, Jacqueline H Finger, Terry F Hayamizu

  • 1The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.

Nucleic Acids Research
|October 29, 2013
PubMed
Summary
This summary is machine-generated.

The Gene Expression Database (GXD) provides comprehensive mouse gene expression data, integrating diverse experimental results and enhancing search capabilities for developmental biology research.

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Area of Science:

  • Developmental Biology
  • Genomics
  • Bioinformatics

Background:

  • The Gene Expression Database (GXD) is a vital resource for mouse developmental expression information.
  • It compiles data from various experimental methods, including RNA in situ hybridization and immunohistochemistry.
  • GXD integrates with Mouse Genome Informatics (MGI) and other databases for broader biological context.

Purpose of the Study:

  • To report on the enhancements and expanded utility of the Gene Expression Database (GXD).
  • To highlight new features for searching and displaying mouse gene expression data.
  • To showcase the integration of GXD with other biological resources.

Main Methods:

  • Data acquisition from scientific literature and researcher contributions.
  • Integration of diverse expression data types (RNA in situ, IHC, RT-PCR, etc.) from wild-type and mutant mice.
  • Development of enhanced web interface features for data searching and visualization.

Main Results:

  • GXD now includes over 1.4 million expression results and 250,000 images.
  • New search functionalities allow users to find expression data linked to specific phenotypes and human diseases.
  • Enhanced displays combine image data with associated annotations for improved understanding.

Conclusions:

  • The Gene Expression Database (GXD) has significantly improved its utility through data expansion and enhanced search/display features.
  • These advancements facilitate deeper insights into mouse gene expression patterns during development.
  • GXD continues to be a crucial, community-driven resource for biological and biomedical research.