Metastatic squamous cell carcinoma thyroid from functionally cured cancer cervix.
Mohana Vamsy1, Palanki Satya Dattatreya, Lella Yugandhar Sarma
1Department of Surgical Oncology, OMEGA Hospitals, A Unit of Hyderabad Institute of Oncology, Banjara Hills, Hyderabad, Andhra Pradesh, India.
Summary
A rare case of metastatic squamous cell carcinoma to the thyroid gland occurred 12 years after cervical cancer treatment. This aggressive cancer rapidly spread to the lungs and bones despite therapy.
Area of Science:
- Oncology
- Pathology
Background:
- Metastasis from cervical cancer to the thyroid is rare.
- Long-term surveillance of treated cervical cancer patients is crucial.
Observation:
- A patient with a history of treated squamous cell carcinoma of the cervix presented with an unusual thyroid metastasis.
- The primary cervical cancer site showed no evidence of recurrence.
Findings:
- The metastatic thyroid carcinoma exhibited rapid progression and widespread dissemination to the lungs and bones.
- The aggressive nature of the metastatic disease was evident despite concurrent chemoradiotherapy.
Implications:
- This case highlights the potential for late metastasis from cervical cancer.
- It underscores the importance of considering unusual metastatic sites in cancer follow-up.
- The rapid progression suggests a need for further research into aggressive metastatic patterns.
Related Concept Videos
02:30Metastasis
5.5K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.5K
01:24Cellular Adaptation IV: Dysplasia and Metaplasia
70
DysplasiaDysplasia refers to abnormal changes in the size, shape, and organization of mature cells, characterized by pleomorphism, nuclear abnormalities, and increased mitotic activity. It commonly affects epithelial tissues, including the cervix, gastrointestinal tract, respiratory mucosa, and endometrium. Although it may occur alongside hyperplasia, dysplasia is not a true adaptive response but a preneoplastic change with potential to progress to cancer.When confined above the basement...
70
01:30Skin Cancer
5.2K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
5.2K
01:12Loss of Tumor Suppressor Gene Functions
5.0K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
5.0K