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The liver plasma membrane Ca2+ pump: hormonal sensitivity.

S Lotersztajn, R Epand, A Mallat

    Biochimie
    |October 1, 1985
    PubMed
    Summary
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    Hormones like glucagon and calcium-mobilizing agents inhibit the liver plasma membrane calcium pump, which removes calcium from cells. This inhibition prolongs elevated intracellular calcium levels, potentially mediating hormone actions.

    Area of Science:

    • Cellular Physiology
    • Endocrinology
    • Membrane Transport

    Background:

    • The liver plasma membrane calcium pump (Ca2+ pump) is crucial for extruding cytosolic calcium from liver cells.
    • This Ca2+ pump is characterized by its plasma membrane localization, high-affinity Ca2+-stimulated ATPase activity, and a phosphorylated intermediate.

    Purpose of the Study:

    • To review the mechanism by which glucagon inhibits the liver plasma membrane Ca2+ pump.
    • To differentiate glucagon's inhibition mechanism from that of calcium-mobilizing hormones.
    • To elucidate the physiological significance of this hormonal inhibition in regulating cytosolic free Ca2+.

    Main Methods:

    • Review of existing literature on liver plasma membrane Ca2+ pump function and regulation.
    • Analysis of studies detailing the effects of glucagon and various calcium-mobilizing hormones (alpha 1-adrenergic agonists, vasopressin, angiotensin II) on Ca2+ pump activity.

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    Main Results:

    • The liver Ca2+ pump is a target for hormonal regulation, with glucagon and calcium-mobilizing hormones inhibiting its activity.
    • Distinct mechanisms underlie the inhibition of the Ca2+ pump by glucagon compared to calcium-mobilizing hormones.

    Conclusions:

    • Inhibition of the liver plasma membrane Ca2+ pump by glucagon and calcium-mobilizing hormones is a key regulatory event.
    • This inhibition leads to a prolonged elevation in cytosolic free Ca2+, contributing to the overall physiological actions of these hormones.