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Updated: May 6, 2026

Isolation of Brain-infiltrating Leukocytes
Published on: June 13, 2011
Progressive multifocal leukoencephalopathy in an immunocompetent patient?
Krisztina K Johansen1, Sverre H Torp, Jana Rydland
1Department of Neurology, St Olavs University Hospital, Trondheim, Norway ; Department of Neuroscience, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim, Norway.
Background:
Progressive multifocal leukoencephalopathy (PML) is a rapidly progressive, potentially fatal, demyelinating disease affecting immunosuppressed patients. PML is rarely reported in cases with no underlying disease or immunosuppression-associated condition.
Case Report:
We present a 72-year-old previously healthy woman who developed a progressive neurological condition affecting the entire nervous system which led to her death within 5 months. PML was diagnosed at autopsy.
Conclusion:
PML should be considered in patients with progressive neurological disorders involving the white matter, even in the absence of previous immunomodulatory treatment or immunosuppression.
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