Related Experiment Video
Updated: May 6, 2026
High-Throughput Dissociation and Orthotopic Implantation of Breast Cancer Patient-Derived Xenografts
Published on: December 20, 2024
Routine histopathologic characteristics can predict oncotype DX(TM) recurrence score in subsets of breast cancer
Malcolm D Mattes1, Justin M Mann, Hani Ashamalla
1Radiation Oncology Department, NY Methodist Hospital, Weill Medical College of Cornell University, Brooklyn, New York, USA,1.
Abstract:
This study assessed whether routine pathologic parameters could predict Oncotype DX(TM) recurrence score (RS) in 72 breast cancers diagnosed from 2008-2012. Comparing patients with low RS (0-17) vs. intermediate RS (18-30) vs. high RS (>30), the mean Nottingham score increased (5.5 vs. 6.3 vs. 7.2, respectively, p = .001) and the mean PR Allred score decreased (6.7 vs. 4.9 vs. 3.3, respectively, p = .001). A high RS was least likely for low-grade tumors (0% had high RS, p = .005), and strong PR positivity (9% had high RS, p = .017). A low RS was least likely for cancers that were both high grade and PR weak/negative.
