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Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...

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Related Experiment Video

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High Resolution Whole Mount In Situ Hybridization within Zebrafish Embryos to Study Gene Expression and Function
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Clustered homeo boxes are differentially expressed during murine development.

A M Colberg-Poley, S D Voss, K Chowdhury

    Cell
    |November 1, 1985
    PubMed
    Summary

    This study details the genomic organization and expression of two murine homeobox genes, m6-12 and m5-4. Both genes are induced during embryonal carcinoma cell differentiation, with differential expression observed in embryonic and adult tissues.

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    Area of Science:

    • Developmental Biology
    • Genomics
    • Gene Expression

    Background:

    • Homeobox genes play critical roles in embryonic development and cell differentiation.
    • A cluster of homeobox genes, including m6-12, has been identified in murine genomic DNA.

    Purpose of the Study:

    • To elucidate the genomic organization of a homeobox gene cluster.
    • To determine the nucleotide sequence and expression patterns of a novel homeobox gene, m5-4.
    • To analyze the differential expression of homeobox genes in embryonic and adult tissues.

    Main Methods:

    • Genomic DNA sequencing to establish gene organization.
    • RNA transcript analysis to study gene expression patterns.
    • Differentiation induction of embryonal carcinoma cells.

    Main Results:

    • The genomic organization of a homeobox cluster was established.
    • The nucleotide sequence of the m5-4 homeobox gene was determined.
    • Expression of m5-4 transcripts, like m6-12, is induced during embryonal carcinoma cell differentiation.
    • m6-12 transcripts are present throughout prenatal development, while m5-4 is restricted to 12-day embryonic tissue.
    • Differential expression patterns were observed in various adult tissues.

    Conclusions:

    • The m6-12 and m5-4 homeobox genes exhibit distinct expression profiles during development.
    • These findings contribute to understanding the role of homeobox genes in mammalian development and differentiation.