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Yeast Signaling

Yeast Signaling

Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...

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Updated: May 6, 2026

Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model

Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model

Published on: September 29, 2011

Approaches to study yeast cell aging and death.

Mario G Mirisola¹, Ralf J Braun, Dina Petranovic

¹Di.Bi.M.eF. Universita' di Palermo, Palermo, Italy.

FEMS Yeast Research

|October 30, 2013

Summary

Yeast, a model organism for 50 years, is crucial for studying cell aging and programmed cell death. This review covers methods like lifespan assessments and viability markers to understand these processes in yeast.

Keywords:

Saccharomyces cerevisiae chronological life span oxidative stress replicative life span yeast cell death yeast survival

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Last Updated: May 6, 2026

Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model

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Published on: September 29, 2011

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Area of Science:

Microbiology and Molecular Biology
Cellular Biology
Biogerontology

Background:

Yeast has been utilized for fermentation for millennia.
Yeast has served as a model organism in research for approximately 50 years.
For the past 15 years, yeast has been instrumental in investigating the molecular mechanisms of cellular aging and programmed cell death.

Purpose of the Study:

To provide a comprehensive overview of current methodologies for studying cell aging in yeast.
To detail approaches for investigating programmed cell death in yeast.
To highlight the utility of yeast as a model system for aging research.

Main Methods:

Lifespan assessments in yeast populations.
Calorie restriction as an intervention to study aging.
Cell viability, survival, and death marker assays.

Main Results:

The review synthesizes various techniques applicable to yeast aging and death studies.
It establishes yeast as a powerful system for dissecting fundamental aging pathways.
Different methods allow for quantitative and qualitative analysis of cellular aging and death.

Conclusions:

Yeast offers a robust and versatile platform for aging and programmed cell death research.
The discussed methods provide a toolkit for researchers to explore molecular mechanisms of aging.
Further research in yeast can yield insights into aging processes relevant to other organisms.