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Auditory brain-stem evoked potentials in patients undergoing dialysis.
Electroencephalography and Clinical Neurophysiology
|January 1, 1986
Summary
Dialysis impacts auditory brain-stem evoked potentials (ABEPs) in renal failure patients, showing abnormalities linked to calcium levels and acute changes post-dialysis. These findings highlight auditory pathway dysfunction in kidney disease.
Area of Science:
- Neuroscience
- Nephrology
- Audiology
Background:
- Renal failure and dialysis can affect neurological function.
- Auditory brain-stem evoked potentials (ABEPs) assess auditory pathway integrity.
Purpose of the Study:
- To investigate auditory pathway function in patients with renal failure undergoing dialysis.
- To evaluate the chronic and acute effects of dialysis on ABEPs and blood chemistry.
Main Methods:
- ABEPs and pure-tone audiograms were recorded in 38 dialysis patients and 40 controls.
- Blood chemistry, including calcium, was analyzed before and after dialysis sessions.
- ABEPs were measured at click rates of 10/sec and 55/sec.
Main Results:
- 24% of patients showed ABEP abnormalities at 10/sec, increasing to 44% at 55/sec.
- Abnormalities included prolonged peak and interpeak latencies.
- Pre-dialysis calcium levels differed between patients with and without ABEP abnormalities.
- Dialysis caused acute changes in blood chemistry, ABEP latencies, and interpeak latencies.
- Acute effects on calcium correlated with changes in ABEP latencies.
Conclusions:
- Renal failure and dialysis induce chronic and acute changes in the auditory brain-stem pathway.
- ABEPs, particularly at higher stimulus rates, reveal dysfunction in dialysis patients.
- Calcium levels and dialysis-induced fluctuations are implicated in auditory pathway alterations.
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