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Published on: February 22, 2022
What is wrong with meta-analysis? The importance of clinical heterogeneity in myocardial regeneration research
1Division of Cardiology, EPICORE Centre, University of Alberta, 220 College Plaza, Edmonton, AB, Canada, T6G 2C8. marcelo.shibata@ualberta.ca.
Abstract:
The author discusses the significance and potential pitfalls in performing a meta-analysis underscoring the importance of a usual forgotten issue in meta-analysis called clinical heterogeneity. Clinical heterogeneity can mislead results and misinform clinicians. Practical examples from the literature are given, and the results of meta-analyses are compared with the results of subsequent large randomised clinical trials addressing similar questions from a historical and contemporary point of view, highlighting clinical heterogeneity. The contemporary aspect culminates with the presentation of a meta-analysis evaluating myocardial cell regeneration with an emphasis in clinical heterogeneity, helping clinicians to understand the issue and better appraise future meta-analyses.
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