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Laboratory Techniques Used to Maintain and Differentiate Biotypes of Vibrio cholerae Clinical and Environmental Isolates
Published on: May 30, 2017
The hows and whys of constructing a native recombinant cholera vaccine
Mina Boustanshenas1, Bita Bakhshi1
1Department of Bacteriology; Faculty of Medical Sciences; Tarbiat Modares University; Tehran, Iran.
Abstract:
Emergence of different ctxB genotypes within virulent Vibrio cholerae populations accentuates the need to develop a vaccine that has the potential to protect against all cholera toxin genotypes. Oral administration of rCTB-alone and in combination with 2 dominant domestic killed whole cells of V. cholerae (O1 Ogawa El Tor and O1 Inaba El Tor) plus one standard V. cholerae (O1 Ogawa classic ATCC 14035)-has shown satisfactory protection as a potent vaccine candidate against toxigenic V. cholerae.
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