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Linking the SWI/SNF complex to prostate cancer

Ryan S Lee1, Charles W M Roberts

  • 1Department of Pediatric Oncology, Dana-Farber Cancer Institute, the Division of Hematology-Oncology, Boston Children's Hospital and the Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA.

Nature Genetics
|October 30, 2013
PubMed
Summary

Aggressive prostate tumors utilize SChLAP1, a long noncoding RNA, to drive cancer progression. SChLAP1 disrupts SNF5, a key component of the SWI/SNF chromatin-remodeling complex, promoting tumor growth.

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