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Enterohepatic bacterial infections dysregulate the FGF15-FGFR4 endocrine axis
Guillaume Romain, Sarah Tremblay, Ellen T Arena
1Department of Microbiology and Infectious Diseases, Faculty of Medicine and Health Sciences, University of Sherbrooke, Cancer Research Pavilion, Rm Z8-1072, 3201, rue Jean-Mignault, Sherbrooke, Québec J1E 4K8, Canada. alfredo.menendez@usherbrooke.ca.
BMC Microbiology
|October 30, 2013
Summary
Enterohepatic bacterial infections disrupt the FGF15/19-FGFR4 endocrine axis, impacting bile acid and lipid metabolism. This disruption links infections to metabolic disorders.
Area of Science:
- Endocrinology
- Gastroenterology
- Metabolic Research
Background:
- Enterohepatic bacterial infections impact physiological processes.
- Fibroblast growth factor 15/19 (FGF15/19) regulates glucose, lipid, and bile acid metabolism.
- FGF15/19 signals via the FGFR4-βKlotho complex in the liver.
Purpose of the Study:
- To investigate the in vivo effects of enterohepatic bacterial infection on the FGF15 endocrine axis.
- To understand the link between bacterial infections and metabolic regulation.
Main Methods:
- Examined in vivo effects of bacterial infection.
- Measured intestinal and hepatic gene expression.
- Assessed gallbladder bile volume, hepatic cholesterol, and triglyceride levels.
Main Results:
- Infection reduced intestinal Fgf15 expression and hepatic FGFR4/βKlotho components.
- Observed altered hepatobiliary gene expression, reduced bile volume, and lipid accumulation.
- Decreased Fgf15 expression correlated with liver bacterial colonization and hepatobiliary issues.
Conclusions:
- Enterohepatic bacterial pathogens disrupt the FGF15/19-FGFR4 endocrine axis homeostasis.
- Disruptions in FGF15/19-FGFR4 signaling may link infections to metabolic and nutritional disorders.
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