Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

1.2K
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
1.2K
Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

2.9K
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
2.9K
Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices01:28

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

216
Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...
216
Drug Delivery: Overview01:16

Drug Delivery: Overview

1.3K
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
1.3K
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

3.0K
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
3.0K
Intrauterine Drug Delivery Systems01:21

Intrauterine Drug Delivery Systems

170
Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
170

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Outreach and Partnership Programs for Conservation Education Where Endangered Species Conservation and Research Occur.

Conservation biology : the journal of the Society for Conservation Biology·2022
Same author

Federally qualified health centers reduce the primary care provider gap in health professional shortage counties.

Nursing outlook·2018
Same author

Nurses Improve Their Communities' Health Where They Live, Learn, Work, and Play.

Policy, politics & nursing practice·2017
Same author

Corrigendum to "Estimating and preventing hospital internal turnover of newly licensed nurses: A panel survey" [Int. J. Nursing Stud. 60 (August) (2016) 251-262].

International journal of nursing studies·2016
Same author

Estimating and preventing hospital internal turnover of newly licensed nurses: A panel survey.

International journal of nursing studies·2016
Same author

Determinants of job satisfaction for novice nurse managers employed in hospitals.

Health care management review·2016

Related Experiment Video

Updated: May 6, 2026

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability
07:41

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability

Published on: July 12, 2024

4.0K

Needle-free drug delivery.

Carol Brewer1

  • 1Advanced Nurse Practitioner, Vascular Access, Oxford University Hospitals.

British Journal of Nursing (Mark Allen Publishing)
|October 30, 2013
PubMed
Summary

Developing needle-free injection devices aims to improve medication delivery. However, achieving pain-free and clinically effective administration for all drugs remains a significant challenge.

Area of Science:

  • Biomedical Engineering
  • Pharmaceutics
  • Drug Delivery Systems

Background:

  • Traditional needle injections cause pain and anxiety, limiting patient compliance.
  • Necessity drives innovation in alternative drug administration methods.
  • Current needle-free technologies face challenges in efficacy and broad applicability.

Purpose of the Study:

  • To review the driving forces behind needle-free injection device development.
  • To assess the current state and limitations of needle-free injection technologies.
  • To identify unmet needs in achieving universally effective and pain-free drug delivery.

Main Methods:

  • Literature review of needle-free injection technologies.
  • Analysis of clinical effectiveness and patient-reported pain data.

More Related Videos

Dissolving Microneedle Array Patches Manufactured By Solvent Casting Technique and Essential Characterization of Microneedle-Based Biomedical Devices
08:26

Dissolving Microneedle Array Patches Manufactured By Solvent Casting Technique and Essential Characterization of Microneedle-Based Biomedical Devices

Published on: January 30, 2026

521
Microinjectrode System for Combined Drug Infusion and Electrophysiology
08:30

Microinjectrode System for Combined Drug Infusion and Electrophysiology

Published on: November 13, 2019

9.0K

Related Experiment Videos

Last Updated: May 6, 2026

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability
07:41

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability

Published on: July 12, 2024

4.0K
Dissolving Microneedle Array Patches Manufactured By Solvent Casting Technique and Essential Characterization of Microneedle-Based Biomedical Devices
08:26

Dissolving Microneedle Array Patches Manufactured By Solvent Casting Technique and Essential Characterization of Microneedle-Based Biomedical Devices

Published on: January 30, 2026

521
Microinjectrode System for Combined Drug Infusion and Electrophysiology
08:30

Microinjectrode System for Combined Drug Infusion and Electrophysiology

Published on: November 13, 2019

9.0K
  • Identification of technological gaps and future research directions.

    • Main Results:

    • Numerous necessities have spurred the creation of various needle-free injection systems.
    • Despite advancements, no single needle-free device can effectively and painlessly deliver all types of medications.
    • Challenges persist in achieving consistent clinical efficacy and patient comfort across diverse drug formulations.

    Conclusions:

    • Needle-free injection technology is advancing due to significant unmet needs.
    • Further innovation is required to overcome existing limitations for widespread, effective adoption.
    • Achieving pain-free and clinically effective delivery for all medications via needle-free devices remains an ongoing research goal.