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Reduced Klotho is associated with the presence and severity of coronary artery disease

Juan F Navarro-González1, Javier Donate-Correa, Mercedes Muros de Fuentes

  • 1Research Division, Hospital Universitario Nuestra Señora de Candelaria, , Santa Cruz de Tenerife, Spain.

Heart (British Cardiac Society)
|October 30, 2013
PubMed

Insights

Lower Klotho levels are linked to coronary artery disease (CAD). This study found reduced serum Klotho and gene expression in patients with significant CAD, indicating Klotho

Area of Science:

  • Cardiovascular Biology
  • Molecular Medicine
  • Genetics

Background:

  • Klotho plays a role in maintaining vascular health.
  • Reduced Klotho has been implicated in various age-related diseases.

Purpose of the Study:

  • To investigate the association between Klotho and coronary artery disease (CAD).
  • To evaluate serum soluble Klotho concentrations and vascular Klotho gene expression in relation to CAD presence and severity.

Main Methods:

  • Cross-sectional study involving 371 subjects undergoing coronary angiography and 70 cardiac surgery patients.
  • Assessed CAD presence and severity (stenosis index), cardiovascular risk factors, Klotho gene expression (thoracic aorta), and serum Klotho levels.

Main Results:

  • Significantly lower serum Klotho concentrations in patients with significant CAD (p<0.001).
  • Higher serum Klotho levels correlated with lower stenosis severity (p<0.0001).
  • Reduced Klotho gene expression observed in patients with significant CAD (p=0.01).

Conclusions:

  • Significant CAD is associated with lower serum Klotho concentrations and reduced vascular Klotho gene expression.
  • These findings suggest Klotho is independently associated with CAD presence and severity, irrespective of traditional risk factors.
Abstract

Keywords:
Coronary Artery Disease

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