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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
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Related Experiment Video

Updated: May 6, 2026

Surgical Model for Single-Staged Tissue-Engineered Urothelial Tubes in Minipigs
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Published on: July 5, 2024

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[Stem cell therapy and tissue engineering in regenerative urology].

M Vaegler1, B Amend, W Aicher

  • 1Klinik für Urologie, Universitätsklinik Tübingen, Eberhard-Karls-Universität Tübingen, Hoppe-Seyler-Straße 3, 72076, Tübingen, Deutschland.

Der Urologe. Ausg. A
|October 30, 2013
PubMed
Summary

Stem cell therapy shows promise for treating lower urinary tract dysfunctions and defects, offering a potential new avenue for regenerative medicine in urology. Further research is validating its efficacy for conditions like erectile dysfunction and incontinence.

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Area of Science:

  • Regenerative Medicine
  • Urology
  • Tissue Engineering

Context:

  • No established tissue engineering therapy exists for lower urinary tract dysfunction.
  • Stem cell treatments are being explored for bladder storage/voiding issues, erectile dysfunction, and urothelial defects.

Purpose:

  • To investigate the potential of stem cell therapy for lower urinary tract regeneration.
  • To evaluate stem cell properties like administration, migration, and differentiation for therapeutic efficiency.

Summary:

  • Over the past decade, research has characterized stem cell populations and evaluated urological therapy options.
  • Key factors for successful tissue regeneration, including angiogenesis and innervation, have been a focus.
  • Studies explored optimal stem cell administration, migration, secretion of bioactive factors, and differentiation stages.

Impact:

  • Stem cell therapy offers a potential solution for unmet needs in lower urinary tract reconstruction.
  • Clinical indications, including post-prostatectomy treatments for incontinence and erectile dysfunction, are being verified in trials.