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CD137 as a biomarker for tumor-reactive T cells: finding gold in the desert
1Authors' Affiliations: Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado; and Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut.
Abstract:
Although human cancer is often surrounded by immune cells, only a small number are tumor-reactive T cells that recognize the tumor antigens and are able to eliminate the cancer cells. Ye and colleagues now found that many of these tumor-reactive T cells are marked by expressing CD137, a T-cell costimulatory receptor.
