Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ultrastructural changes in Sertoli cells in ageing humans.

R Paniagua, P Amat, M Nistal

    International Journal of Andrology
    |August 1, 1985
    PubMed
    Summary

    Aging in men affects sperm production due to changes in Sertoli cells within seminiferous tubules. These cellular alterations correlate with increased gonadotrophin levels, impacting germ cell development.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Use of compounds naturally labeled with stable isotopes for the study of the metabolism of glycoprotein neutral sugars by gas-liquid chromatography-isotope-ratio mass spectrometry. Technical validation in the rat.

    Carbohydrate research·1992
    Same author

    Potent gp120-like neurotoxic activity in the cerebrospinal fluid of HIV-infected individuals is blocked by peptide T.

    Brain research·1992
    Same author

    Lateralized mediation of arousal and habituation: differential bilateral electrodermal activity in unilateral temporal lobectomy patients.

    Neuropsychologia·1992
    Same author

    Transfusion-associated graft-versus-host disease, monoclonal gammopathy and PCR.

    British journal of haematology·1992
    Same author

    What do patients want to know about their inflammatory bowel disease?

    The Italian journal of gastroenterology·1992
    Same author

    Phosphatidate phosphohydrolases in liver, heart and adipose tissue of the JCR:LA corpulent rat and the lean genotypes: implications for glycerolipid synthesis and signal transduction.

    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity·1992

    Area of Science:

    • Reproductive biology
    • Cell biology
    • Gerontology

    Background:

    • Aging men experience changes in testicular function.
    • Sertoli cells are crucial for spermatogenesis.
    • Previous studies indicate potential alterations in Sertoli cells with age.

    Purpose of the Study:

    • To investigate the ultrastructural changes in Sertoli cells of aging men.
    • To correlate these changes with spermatogenetic status and hormone levels.

    Main Methods:

    • Ultrastructural analysis of seminiferous tubules from aging men.
    • Morphological classification of Sertoli cells based on cytoplasmic and nuclear features.
    • Correlation analysis with gonadotrophin levels.

    Main Results:

    • Approximately 50% of Sertoli cells showed altered cytoplasm despite mature nuclear appearance.
    • Identified variations included lipid droplets, cytoplasmic vacuoles, multinucleation, and mitochondrial changes.
    • A subset of Sertoli cells exhibited immature nuclear features, suggesting dedifferentiation.
    • Increased gonadotrophin levels correlated with altered germ cell development and Sertoli cell morphology.

    Conclusions:

    • Aging in men is associated with significant ultrastructural changes in Sertoli cells.
    • These Sertoli cell alterations are linked to impaired spermatogenesis and hormonal shifts.
    • Sertoli cell dedifferentiation may occur during the aging process.

    Related Experiment Videos