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Clear cell chondrosarcoma: Cytologic findings in six cases.

Xiaoyin Sara Jiang1, Liron Pantanowitz, Marilyn M Bui

  • 1Department of Pathology, Duke University Medical Center, Durham, North Carolina.

Diagnostic Cytopathology
|October 30, 2013
PubMed
Summary

Clear cell chondrosarcoma (CCCS) is a rare bone tumor. Fine needle aspiration and cell block analysis are crucial for accurate diagnosis, aiding in distinguishing it from other bone lesions.

Keywords:
clear cell chondrosarcomafine needle aspirationneedle biopsy

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Area of Science:

  • Oncology
  • Cytopathology
  • Skeletal Radiology

Background:

  • Clear cell chondrosarcoma (CCCS) is a rare chondrosarcoma subtype.
  • Typically affects adults, often in long bone epiphyses.
  • Preoperative diagnosis is challenging due to rarity and imaging overlap with other lesions.

Observation:

  • Presents six cases of CCCS diagnosed via fine needle aspiration (FNA) and/or touch preparations.
  • Cytologic findings include plasmacytoid cells with foamy cytoplasm.
  • Extracellular chondroid matrix material is also observed.

Findings:

  • The "clear cell" morphology on cell block material was key for definitive diagnosis.
  • Cytology effectively identified characteristic features of CCCS.
  • Distinguishing CCCS from mimics was achieved through detailed cytologic analysis.

Implications:

  • Highlights the utility of FNA and cell block analysis in diagnosing CCCS.
  • Emphasizes the importance of recognizing specific cytologic features for accurate preoperative diagnosis.
  • Aids in differentiating CCCS from other bone tumors, potentially improving patient management.