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Clear cell chondrosarcoma: Cytologic findings in six cases.
Xiaoyin Sara Jiang1, Liron Pantanowitz, Marilyn M Bui
1Department of Pathology, Duke University Medical Center, Durham, North Carolina.
Diagnostic Cytopathology
|October 30, 2013
Summary
Clear cell chondrosarcoma (CCCS) is a rare bone tumor. Fine needle aspiration and cell block analysis are crucial for accurate diagnosis, aiding in distinguishing it from other bone lesions.
Area of Science:
- Oncology
- Cytopathology
- Skeletal Radiology
Background:
- Clear cell chondrosarcoma (CCCS) is a rare chondrosarcoma subtype.
- Typically affects adults, often in long bone epiphyses.
- Preoperative diagnosis is challenging due to rarity and imaging overlap with other lesions.
Observation:
- Presents six cases of CCCS diagnosed via fine needle aspiration (FNA) and/or touch preparations.
- Cytologic findings include plasmacytoid cells with foamy cytoplasm.
- Extracellular chondroid matrix material is also observed.
Findings:
- The "clear cell" morphology on cell block material was key for definitive diagnosis.
- Cytology effectively identified characteristic features of CCCS.
- Distinguishing CCCS from mimics was achieved through detailed cytologic analysis.
Implications:
- Highlights the utility of FNA and cell block analysis in diagnosing CCCS.
- Emphasizes the importance of recognizing specific cytologic features for accurate preoperative diagnosis.
- Aids in differentiating CCCS from other bone tumors, potentially improving patient management.
