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Concise review: stem/progenitor cells for renal tissue repair: current knowledge and perspectives

Shikhar Aggarwal1, Aldo Moggio, Benedetta Bussolati

  • 1Department of Molecular Biotechnology and Life Sciences, Molecular Biotechnology Center, University of Torino, Torino, Italy.

Stem Cells Translational Medicine
|October 30, 2013
PubMed

Insights

Identifying renal stem/progenitor cells is key for kidney regeneration. This review explores current knowledge on stem cells and their bioproducts for repairing kidney injury and discusses future organ generation strategies.

Area of Science:

  • Nephrology
  • Stem Cell Biology
  • Regenerative Medicine

Background:

  • Kidney regeneration is limited due to specialized cell types.
  • The identity and niche of renal stem/progenitor cells remain debated.
  • Current therapies focus on enhancing intrinsic kidney repair capabilities.

Purpose of the Study:

  • To review current knowledge on stem/progenitor cells for kidney regeneration.
  • To discuss bioproducts from stem/progenitor cells for therapeutic effects.
  • To survey novel approaches for nephrogenesis and organ generation.

Main Methods:

  • Review of existing literature on renal stem/progenitor cells.
  • Analysis of therapeutic effects of endogenous and exogenous cells in kidney injury models.
  • Survey of organoid, decellularized kidney, and blastocyst complementation strategies.

Main Results:

  • Stem/progenitor cells and their bioproducts show therapeutic potential in kidney regeneration.
  • Mesenchymal stem cells are a focus for clinical translation.
  • Extracellular vesicles offer a promising approach for cell reprogramming.

Conclusions:

  • Understanding renal stem/progenitor cells is crucial for developing effective kidney regeneration therapies.
  • Stem cell-derived bioproducts represent a promising avenue for treating kidney injury.
  • Advanced techniques like organoids and blastocyst complementation may enable future kidney organogenesis.
Keywords:
KidneyMarrow stromal stem cellsProgenitor cellsRenal

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