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Reduced paraoxonase 1 activity as a marker for severe coronary artery disease

Chiyan Zhou1, Jia Cao, Liang Shang

  • 1Department of Biochemistry and Molecular Biology, Wuhan University School of Medicine, Wuhan, Hubei 430071, China.

Disease Markers
|October 30, 2013
PubMed

Insights

Plasma paraoxonase-1 (PON1) activity is lower in patients with coronary artery disease (CAD). Lower PON1 levels correlate with increased atherosclerosis severity, suggesting PON1 may serve as a biomarker for CAD progression.

Area of Science:

  • Biochemistry
  • Cardiovascular Medicine
  • Immunology

Background:

  • Paraoxonase-1 (PON1) is an HDL-associated enzyme with potential anti-atherogenic properties.
  • Atherosclerosis is a chronic inflammatory disease characterized by plaque buildup in arteries.

Purpose of the Study:

  • To investigate the relationship between plasma PON1 activity and the progression of atherosclerosis and coronary artery disease (CAD).

Main Methods:

  • Collected fasting blood samples from female apolipoprotein E-deficient (apoE(-/-)) mice and 149 patients undergoing coronary angiography.
  • Measured biochemical parameters, including plasma PON1 activity.
  • Assessed CAD severity using the Gensini score (GSS).

Main Results:

  • Aged apoE(-/-) mice exhibited lower PON1 activity, negatively correlated with atherosclerotic lesion size and inflammatory markers (IL-6, TNF-α).
  • In patients, PON1 activity correlated with age, sex, HDL-cholesterol, apolipoprotein AI, and hs-CRP.
  • PON1 activity was significantly lower in the CAD group and further reduced in severe CAD (GSS > 40) compared to mild/moderate CAD.
  • A significant negative correlation was found between PON1 activity and GSS (r = -0.393, P < 0.001).

Conclusions:

  • Plasma PON1 activity is reduced in patients with CAD and correlates negatively with disease severity.
  • PON1 activity may serve as a potential biomarker for assessing the severity of coronary artery disease.

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