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Association between angiotensin II type 1 receptor polymorphism and sudden cardiac death in myocardial infarction

Peter Kruzliak1, Gabriela Kovacova, Olga Pechanova

  • 1Institute of Normal and Pathological Physiology and Centre of Excellence for Regulatory Role of Nitric Oxide in Civilisation Diseases, Slovak Academy of Sciences, Sienkiewiczova 1, 813 71 Bratislava, Slovakia ; Department of Cardiovascular Diseases, International Clinical Research Center, St. Anne's Faculty Hospital and Masaryk University, Pekarska 53, 602 00 Brno, Czech Republic.

Disease Markers
|October 30, 2013
PubMed
Abstract

Insights

The angiotensin II type 1 receptor (AT1R) CC genotype is linked to increased risk of acute coronary syndrome (ACS) and myocardial infarction (MI). This genotype is also associated with more severe ACS and higher risk of sudden cardiac death.

Area of Science:

  • Cardiovascular Genetics
  • Molecular Cardiology
  • Renal Physiology

Background:

  • The renin-angiotensin system plays a role in coronary artery disease (CAD) and myocardial infarction (MI) pathogenesis.
  • Angiotensin II (Ang II) mediates adverse effects like vasoconstriction and vascular remodeling via the angiotensin II type 1 receptor (AT1R).

Purpose of the Study:

  • To investigate the association between angiotensin II type 1 receptor (AT1R) gene polymorphisms and acute coronary syndrome (ACS).
  • To determine if specific AT1R genotypes correlate with MI risk and severity.

Main Methods:

  • A cohort of 1376 individuals was studied, including 749 patients with ACS and 627 healthy controls.
  • Genotyping for the AT1R gene was performed.
  • Clinical outcomes, including MI and sudden cardiac death, were assessed in relation to genotype.

Main Results:

  • Patients with ACS showed a higher prevalence of the AT1R CC genotype compared to controls.
  • The AT1R CC genotype was associated with a 2.76-fold increased risk of MI.
  • The CC genotype correlated with a higher risk of left anterior descending artery infarction, anterior wall infarction, and sudden cardiac death.

Conclusions:

  • The AT1R CC genotype is an independent risk factor for ACS incidence.
  • This genotype is linked to increased ACS severity and a greater risk of sudden cardiac death.

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