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Updated: May 6, 2026
Expression, Purification, and Antimicrobial Activity of S100A12
Published on: May 13, 2017
Fecal S100A12 in healthy infants and children
1Department of Gastroenterology, Sydney Children's Hospital, Sydney 2034, Australia ; School of Women's and Children's Health, University of New South Wales, Sydney 2052, Australia ; Department of Paediatrics, University of Otago (Christchurch), Christchurch 8140, New Zealand.
Insights
Fecal S100A12 levels are typically low in healthy infants and children, below established cut-offs. Elevated levels in children over 12 months may indicate gut disease.
Area of Science:
- Pediatric Gastroenterology
- Biomarker Research
- Inflammatory Disease Markers
Background:
- Fecal S100A12 is a recognized noninvasive marker for gut inflammation.
- Previous studies have not fully characterized S100A12 expression patterns in healthy young children.
Purpose of the Study:
- To determine S100A12 levels in healthy infants and children.
- To establish reference ranges for fecal S100A12 in a pediatric population without gastrointestinal disease.
Main Methods:
- Stool samples were collected from healthy infants (<12 months) and children.
- Faecal S100A12 concentrations were quantified using immunoassay.
Main Results:
- Median S100A12 levels in healthy children were 0.5 mg/kg, with most values below the established cut-off.
- Five infants showed transiently high S100A12 levels (>10 mg/kg) in early infancy.
- No significant gender-based variation in S100A12 levels was observed.
Conclusions:
- In healthy infants and children, fecal S100A12 levels are generally below standard cut-offs.
- Transient elevations of S100A12 may occur in early infancy.
- Elevated S100A12 in children over 12 months strongly suggests underlying organic gut disease.
Background And Aims:
Fecal S100A12 is shown to be a useful noninvasive marker of gut inflammation. However, the studies to date have not characterised the patterns of expression in healthy young children. This study aimed to determine S100A12 levels in infants and children without symptoms of underlying gut disease.
Methods:
Stool samples were collected from healthy infants (<12 months) and children without gastrointestinal symptoms. Faecal S100A12 was measured by immunoassay.
Results:
Fifty-six children were recruited. Serial samples were obtained from seven term infants over the first 6 months of life. Single samples were obtained from 49 healthy children ranging from 0.16 to 13.8 years of age. Median S100A12 levels were 0.5 mg/kg (ranging from 0.39 to 25) in the healthy children, with high values (>10 mg/kg) in five infants only. There was no variation between gender. Median S100A12 levels in healthy infants remained below the established normal cut-off from birth to six months of age.
Conclusion:
S100A12 levels in well infants and children are almost exclusively lower than the standard cut-off. Transiently higher levels may be seen in early infancy. An elevated level of S100A12 in children older than 12 months of age is likely to represent organic gut disease.
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