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Updated: May 6, 2026

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Bone marrow necrosis - initial presentation in sickle cell anemia.

Maria Shafiq1, Natasha Ali

  • 1Department of Pathology and Microbiology, Aga Khan University and Hospital, Karachi, Pakistan.

The American Journal of Case Reports
|October 30, 2013
PubMed
Summary
This summary is machine-generated.

Bone marrow necrosis is a rare complication of sickle cell disease. Early diagnosis via bone trephine biopsy is crucial for timely treatment of this condition.

Keywords:
bone marrownecrosissickle cell

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Area of Science:

  • Hematology
  • Pathology

Background:

  • Sickle cell disease commonly presents with bone involvement, including painful vaso-occlusive crisis and avascular necrosis.
  • Bone marrow necrosis and infarction are other recognized complications.

Purpose of the Study:

  • To report an unusual clinical course of sickle cell disease.
  • To highlight the diagnostic significance of bone marrow necrosis.

Main Methods:

  • A case report of a 20-year-old male with sickle cell anemia.
  • Bone trephine biopsy was performed for evaluation of symptoms including fever, weakness, and bone pain.

Main Results:

  • The bone trephine biopsy revealed extensive central necrosis surrounded by fibroblasts.
  • This finding represents bone marrow necrosis, a less common complication.

Conclusions:

  • Bone marrow necrosis can occur in sickle cell disease.
  • Recognition of necrosis through bone trephine biopsy is vital for prompt therapeutic intervention.