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Updated: May 6, 2026

A TIRF Microscopy Technique for Real-time, Simultaneous Imaging of the TCR and its Associated Signaling Proteins
Published on: March 22, 2012
B lymphocyte antigen receptor signaling: initiation, amplification, and regulation
Thomas A Packard1, John C Cambier
1Integrated Department of Immunology, University of Colorado School of Medicine & National Jewish Health 1400 Jackson St, Denver, CO 80206.
Abstract:
B lymphocytes and their differentiated daughters are charged with responding to the myriad pathogens in our environment and production of protective antibodies. A sample of the protective antibody produced by each clone is utilized as a component of the cell's antigen receptor (BCR). Transmembrane signals generated upon antigen binding to this receptor provide the primary directive for the cell's subsequent response. In this report, we discuss recent progress and current controversy regarding B cell receptor signal initiation, transduction and regulation.
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