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An Orthotopic Murine Model of Human Prostate Cancer Metastasis
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[Lycopene and tomatoes--their effect on prevention of prostatic cancer]

Tali Silberstein1, Eldad Silberstein, Oshra Saphier

  • 1Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Harefuah
|October 31, 2013
PubMed

Insights

Lycopene, an antioxidant in red fruits, shows promise in preventing prostate cancer. This review explores its anti-cancer activity and biological effects for cancer prevention.

Area of Science:

  • Oncology
  • Nutritional Science
  • Carotenoid Research

Background:

  • Prostate cancer is a leading cause of cancer death in men.
  • Microscopic prostate cancer is prevalent, even in younger men.
  • Lycopene is a potent antioxidant found in red fruits and vegetables.

Purpose of the Study:

  • To review the evidence on lycopene's biological activity.
  • To examine lycopene's role in prostate cancer prevention.
  • To discuss lycopene's bioavailability and anti-tumor effects.

Main Methods:

  • Literature review of laboratory and epidemiological studies.
  • Analysis of lycopene's antioxidant and anti-cancer mechanisms.
  • Evaluation of lycopene-rich food consumption and cancer incidence data.

Main Results:

  • Lycopene exhibits significant anti-oxidative activity.
  • Laboratory studies indicate lycopene inhibits tumor growth.
  • Epidemiological data suggests lycopene-rich diets reduce cancer incidence, particularly prostate cancer.

Conclusions:

  • Lycopene demonstrates potential as a chemopreventive agent for prostate cancer.
  • Further research into lycopene's mechanisms and optimal intake is warranted.
  • Dietary lycopene may play a role in reducing prostate cancer risk.

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