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Relationship between left ventricular geometry and soluble ST2 in a cohort of hypertensive patients

Dike B Ojji1, Lionel H Opie, Sandrine Lecour

  • 1Cardiology Unit, Department of Medicine, University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria; Department of Medicine, Faculty of Health Sciences, Hatter Institute for Cardiovascular Research in Africa, University of Cape Town, Cape Town, South Africa.

Journal of Clinical Hypertension (Greenwich, Conn.)
|October 31, 2013
PubMed

Insights

Soluble ST2 levels are higher in patients with concentric hypertrophy compared to normal geometry. This suggests soluble ST2 may help differentiate concentric hypertrophy in hypertensive heart disease.

Area of Science:

  • Cardiology
  • Biomarkers
  • Hypertension Research

Background:

  • Left ventricular hypertrophy (LVH) presents in various geometric patterns.
  • Hypertension-related cardiovascular risks differ by LV geometric pattern.
  • Soluble ST2, a marker of cardiac strain, is elevated in hypertension but its relation to LV geometric patterns is unknown.

Purpose of the Study:

  • To investigate the association between soluble ST2 levels and left ventricular geometric patterns in hypertensive patients.

Main Methods:

  • Echocardiography was used to assess LV geometric patterns.
  • LV mass index defined LVH (men: >49.2 g/m(2.7), women: >46.2 g/m(2.7)).
  • Soluble ST2 levels were measured and compared across geometric groups.

Main Results:

  • Patients with concentric hypertrophy showed significantly higher soluble ST2 levels than those with normal geometry (20.4±8.4 ng/mL vs 14.3±5.4 ng/mL, P<.002).

Conclusions:

  • Soluble ST2 levels are influenced by hypertensive left ventricular changes.
  • Soluble ST2 may serve as a potential biomarker for distinguishing concentric hypertrophy from normal geometry in hypertension.

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