[Studies on tissue-localization of various tumormarkers in ovarian tumors by immunoperoxidase method]

The tissue-localization of carcinoembryonic antigen (CEA), alpha-fetoprotein (AFP), human chorionic gonadotropin (HCG) and immunoglobulin were studied by the "Immunoperoxidase method" (indirect method) in 150 patients with ovarian tumor. The study groups consisted of 86 malignant cases, 28 low-potential malignant cases and 36 benign cases. Positive rates of tumor-markers found in the study group overall were as follow; CEA 24.7%, AFP 7.3%, HCG 6.7%, Ig-G 27.3% and Ig-M 8.0% respectively. The positive rate was significantly higher in the malignant group (33.7%) than in the low-potential malignant group (21.4%) and benign group (5.6%). Similar findings were also obtained for Ig-G among the three groups. CEA was more frequently found in "mucinous cyst adenocarcinoma" and "metastatic ovarian cancer". A positive correlation was found between tissue-localization of CEA and serum level of CEA (p less than 0.05). AFP and HCG were also detected in germ cell tumors with high positive rate, 25.9% and 14.8%, respectively. Regarding the prognosis, the survival rate for the Ig-G positive group was better than for the negative group.