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Related Concept Videos

Blood Transfusion and Agglutination02:45

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
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Related Experiment Video

Updated: May 6, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
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Transfusion immunomodulation from a clinical perspective: an update.

Majed A Refaai1, Neil Blumberg

  • 1Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box-608, Rochester, NY 14642, USA.

Expert Review of Hematology
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PubMed
Summary
This summary is machine-generated.

Allogeneic blood transfusions can alter the immune system, potentially increasing infection risk. Strategies like leukoreduction can mitigate these transfusion immunomodulation effects.

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Area of Science:

  • Immunology
  • Transfusion Medicine
  • Oncology

Background:

  • Allogeneic blood transfusions exert significant immunomodulatory effects on recipients.
  • Transfusion immunomodulation is linked to increased post-operative infection rates and potentially cancer recurrence.
  • The precise mechanisms underlying transfusion immunomodulation remain under investigation.

Purpose of the Study:

  • To review the evidence on transfusion immunomodulation.
  • To discuss the proposed mechanisms of transfusion immunomodulation.
  • To outline strategies for mitigating transfusion-associated immune effects.

Main Methods:

  • Literature review of studies on blood transfusion and immune response.
  • Analysis of data linking transfusion to clinical outcomes.
  • Evaluation of methods to reduce transfusion immunomodulation.

Main Results:

  • Transfusion immunomodulation is a recognized biologic effect, strongly associated with allogeneic leukocytes.
  • Soluble mediators in stored blood products may also contribute to adverse outcomes.
  • Conservative transfusion practices and leukoreduction are effective mitigation strategies.

Conclusions:

  • Transfusion immunomodulation is a clinically relevant phenomenon with established links to post-operative infections.
  • Leukoreduction is a proven method to reduce these effects.
  • Further research into mechanisms and plasma depletion efficacy is warranted.