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Dendritic cells in tolerance and autoimmune diabetes

Sylvie Guerder1, Nathalie Joncker, Karim Mahiddine

  • 1Centre de Physiopathologie de Toulouse Purpan, Université Toulouse III Paul-Sabatier, Toulouse F-31300, France; INSERM, U1043, Toulouse F-31300, France; CNRS, UMR5282, Toulouse F-31300, France.

Current Opinion in Immunology
|October 31, 2013
PubMed

Type 1 diabetes is a T cell mediated autoimmune disease where both central and peripheral mechanisms effect T cell tolerance induction. Dendritic cells (DCs) are key regulators of innate and adaptive immune responses. They significantly contribute to central and peripheral T cell tolerance and, following maturation, induce the activation and differentiation of naïve T cells into effector and memory cells. DCs are also major actors in inflammation. Given these multiple effects on immune responses, DCs are suspected to contribute to autoimmune diseases. In this review we discuss how some specific features of DC may contribute to type 1 diabetes.

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