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Assessment of the Cardiovascular System III: Palpation

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Related Experiment Video

Updated: May 6, 2026

Non-Invasive Monitoring of Microvascular Oxygenation and Reactive Hyperemia using Hybrid, Near-Infrared Diffuse Optical Spectroscopy for Critical Care

Non-Invasive Monitoring of Microvascular Oxygenation and Reactive Hyperemia using Hybrid, Near-Infrared Diffuse Optical Spectroscopy for Critical Care

Published on: May 10, 2024

[Microcirculation characters in the elderly septic patients].

Mo-lei Yan¹, Jing Yan, Jin Chen

¹Intensive Care Unit, Zhejiang Chinese Medical University, Hangzhou 310013, China.

Zhonghua Yi Xue Za Zhi

|October 31, 2013

Summary

This summary is machine-generated.

Elderly patients with septic shock exhibit severe sublingual microcirculatory dysfunction. These microcirculatory alterations, including perfused vessel density, are more pronounced in septic shock and correlate with mortality, suggesting their use in guiding therapy.

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Last Updated: May 6, 2026

Non-Invasive Monitoring of Microvascular Oxygenation and Reactive Hyperemia using Hybrid, Near-Infrared Diffuse Optical Spectroscopy for Critical Care

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Published on: May 10, 2024

In vivo Micro-circulation Measurement in Skeletal Muscle by Intra-vital Microscopy

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Published on: May 28, 2007

Transcutaneous Microcirculatory Imaging in Preterm Neonates

Transcutaneous Microcirculatory Imaging in Preterm Neonates

Published on: December 31, 2015

Area of Science:

Gerontology
Critical Care Medicine
Biomedical Engineering

Context:

Sepsis and septic shock are life-threatening conditions, particularly in elderly populations.
Microcirculatory dysfunction is increasingly recognized as a key pathophysiological mechanism in sepsis.
Assessing microcirculation provides insights into tissue perfusion and organ function.

Purpose:

To investigate sublingual microcirculatory changes in elderly patients with severe sepsis and septic shock.
To compare microcirculatory parameters between septic shock patients, sepsis patients, and healthy elderly individuals.
To evaluate the relationship between microcirculatory alterations and 28-day mortality in sepsis.

Summary:

Elderly patients with sepsis/septic shock displayed significant sublingual microcirculatory dysfunctions compared to healthy controls.
Septic shock patients showed markedly lower perfused vessel density (PDV), proportion of perfused vessels (PPV), and microvascular flow index (MFI) than severe sepsis and non-septic patients.
Microcirculatory parameters (PDV, PPV, MFI) and lactate levels were significantly lower in non-survivors compared to survivors, indicating a correlation with mortality.

Impact:

Sublingual microcirculatory assessment using sidestream darkfield (SDF) imaging can identify severe alterations in elderly septic shock patients.
These microcirculatory abnormalities are more pronounced in septic shock and are associated with higher mortality rates.
Monitoring microcirculatory parameters may offer a valuable tool for guiding therapeutic interventions in sepsis management.